BestAid Collagen Bone Graft (BestAid) is a synthetic bone graft substitute comprised of highly purified type I collagen and hydroxyapatite/tricalcium phosphate granules. It functions as an osteogenic stimulus to which the patient’s bone marrow may be added prior to implantation. The bone graft mimics the composition of natural bone and is biocompatible. BestAid provides an osteoconductive environment for new bone formation. When coated with autogenous bone marrow, the osteoinductive and osteogenic properties of BestAid enable it to be used as a substitute for autogenous bone graft, thus eliminating the need to subject the patient to the potential attendant morbidity as well as the harvesting-related complications and pain associated with the second surgery. The purified fibrillar collagen component has a high constituent of purified bovine tendon Type I collagen. The mineral component is a biphasic mixture of beta-tricalcium phosphate and hydroxyapatite. The HA/β-TCP particles are formed by a sintering process into irregularly shaped granules. The purified fibrillar collagen and HA/β-TCP composite serves as the matrix for osteogenesis process to occur. In situ, the collagen and beta-tricalcium phosphate components of the ceramic are resorbed and replaced by new bone, similar to the resorption and remodeling observed with autogenous bone.

BestAid is indicated for use in bony voids or gaps that are not intrinsic to the stability of the bony structure. The product should be gently packed into bony voids or gaps of the skeletal system (i.e., the extremities, spine and pelvis). These defects may be surgically created osseous defects or osseous defects created from traumatic injury to the bone. The product provides bone void filler that resorbs and is replaced by the growth of new bone during the healing process. The bone graft can be mixed with autogenous bone marrow prior to use at the physician’s discretion. In weight bearing situations, BestAid is to be used in conjunction with internal or external fixation devices. The fracture defect treated with BestAid should not exceed 30 mL.